Kidney Aminopeptidases A and N in Uranyl-Nitrate-lnduced Acute Renal Failure

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The Mechanism of Acute Renal Failure after Uranyl Nitrate ROLAND

Portions of this work were presented at the Annual Meeting of The American Federation for Clinical Research, Atlantic City, N. J., 5 May 1974. Received for publication 21 June 1974 and in revised form 18 November 1974. dose UN (0.047±0.013) and high dose (0.024±0.003 nVs/g kidney wt/mm Hg). Therefore UN decreases GFR by two mechanisms: (a) tubular damage leading to back-diffusion of solutes and...

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In uranyl nitrate (UN)-induced acute renal failure (ARF) glomerular ultrafiltration coefficient (K(f)) decreases because of unknown reasons. Since transport of water across the glomerular capillary wall occurs predominantly extracellularly through the endothelial fenestrae (EF), a reduction in the diameter and/or the density of EF can reduce the extracellular filtration area and the glomerular ...

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The diminished glomerular filtration rate observed in previous studies of acute renal failure induced by uranyl nitrate has been ascribed to backflow of glomerular filtrate through necrotic tubular epithelium, since renal blood flow was essentially normal. Renal blood flow (xenon washout) and renal function were studied serially for 96 hours after the administration of uranyl nitrate (10 mg/kg,...

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No matter in which clinical field you will be working in the future, you will be confronted with cases of acute renal failure. In this acute emergency illness, various pathomechanisms come together and lead to a principally reversible decrease in renal function, often involving disbalances of water and electrolytes. The different types of acute renal failure have to be understood well in order ...

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No matter in which clinical field you will be working in the future, you will be confronted with cases of acute renal failure. In this acute emergency illness, various pathomechanisms come together and lead to a principally reversible decrease in renal function, often involving disbalances of water and electrolytes. The different types of acute renal failure have to be understood well in order ...

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ژورنال

عنوان ژورنال: Nephron

سال: 1997

ISSN: 1423-0186,0028-2766

DOI: 10.1159/000190335